5alpha-androstan-3beta,17beta-diol disulfate to androstenediol (3beta,17beta) monosulfate (2)

Numerator Metabolite

Metabolite Accession: GCST90199835
Name: 5alpha-androstan-3beta,17beta-diol disulfate
Hmdb Id: HMDB00493
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Associated Genomic Regions

Region: rs73079476

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.273
Position:
21343833
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
15.868
Reference Allele:
A
-log10(P):
-128.894
MAF:
0.156
Beta (Num):
0.156
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.117
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Androgen and Steroid Metabolism.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Androgen and Steroid Metabolism.6[1], 7[2], 9[3]

Ratio Explanation:

The ratio likely reflects the balance of hepatic uptake and sulfation of androstenediol, processes in which the transporter SLCO1B1 is implicated.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced function of the SLCO1B1 transporter, due to genetic variants, can alter the clearance of drugs and endogenous molecules like bilirubin and steroids. This impaired hepatic clearance is linked to hyperbilirubinemia and may influence coronary atherosclerosis risk through altered lipid and drug (e.g., statin) metabolism.1[1], 2[2], 10[3], 11[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data