5alpha-androstan-3beta,17beta-diol disulfate to etiocholanolone glucuronide

Numerator Metabolite

Metabolite Accession: GCST90199835
Name: 5alpha-androstan-3beta,17beta-diol disulfate
Hmdb Id: HMDB00493
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of etiocholanolone glucuronide
Metabolite Accession: GCST90199964
Name: etiocholanolone glucuronide
Hmdb Id: HMDB0004484
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs113017476

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.526
Position:
31989359
SE (Ratio):
0.047
Effect Allele:
A
Z-score (Ratio):
-11.170
Reference Allele:
G
-log10(P):
-65.032
MAF:
0.035
Beta (Num):
-0.241
Novel Locus:
No
SE (Num):
0.036
Beta (Den):
0.285
SE (Den):
0.041
No CNV overlap
rQTL cluster:
149
Reaction Distance:
NA
Closest Genes:
MEMO1 DPY30 SPAST XDH SLC30A6

LLM Analysis

Numerator Metabolite Explanation:

Androgen Metabolism / Steroid Sulfation3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Androgen Metabolism / Steroid Glucuronidation6[1], 7[2], 8[3], 9[4]

Ratio Explanation:

The ratio reflects competing androgen clearance pathways, contrasting 5-alpha reduction with sulfation (numerator) against 5-beta reduction with glucuronidation (denominator), potentially regulated transcriptionally by DPY30.6[1], 3[2], 1[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No associated phenotype was provided, so a causal link cannot be established. The eQTL evidence for DPY30 suggests a potential transcriptional regulatory effect on androgen metabolism.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data