5alpha-androstan-3beta,17beta-diol disulfate to glyco-beta-muricholate**

Numerator Metabolite

Metabolite Accession: GCST90199835
Name: 5alpha-androstan-3beta,17beta-diol disulfate
Hmdb Id: HMDB00493
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200179
Name: glyco-beta-muricholate**
Hmdb Id: HMDB0341323
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs148982377

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-1.561
Position:
99075038
SE (Ratio):
0.061
Effect Allele:
C
Z-score (Ratio):
-25.506
Reference Allele:
T
-log10(P):
-328.753
MAF:
0.033
Beta (Num):
-0.672
Novel Locus:
No
SE (Num):
0.036
Beta (Den):
0.889
SE (Den):
0.043
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Secondary bile acid biosynthesis7[1], 8[2], 9[3]

Ratio Explanation:

none

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Alterations in ATP5J2 expression can impact cellular energy metabolism. This may influence inflammatory processes and adipocyte function, potentially contributing to changes in BMI, CRP, and WBC count, while also affecting steroid and bile acid pathways that are linked to uric acid metabolism and body composition.10[1], 11[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:ATP5J2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data