5alpha-pregnan-3beta,20alpha-diol disulfate to androstenediol (3beta,17beta) monosulfate (2)

Numerator Metabolite

Structure of 5alpha-pregnan-3beta,20alpha-diol disulfate
Metabolite Accession: GCST90199838
Name: 5alpha-pregnan-3beta,20alpha-diol disulfate
Hmdb Id: HMDB0094650
Super Pathway: NA
Sub Pathway: NA
Inchikey: LSQGWMYMIHQKSA

Denominator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Associated Genomic Regions

Region: rs73079476

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.299
Position:
21343833
SE (Ratio):
0.024
Effect Allele:
C
Z-score (Ratio):
12.486
Reference Allele:
A
-log10(P):
-80.703
MAF:
0.156
Beta (Num):
0.182
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
-0.117
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis, Pregnenolone and Progestin Steroid Metabolism.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Androgen and Steroid Metabolism.10[1], 11[2]

Ratio Explanation:

The ratio reflects the relative hepatic uptake of sulfated pregnane and androstenediol steroids, which is modulated by the transport efficiency of SLCO1B1.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function can alter steroid hormone and bilirubin levels, contributing to an increased risk of coronary atherosclerosis and affecting hematological and metabolic traits.12[1], 13[2], 14[3], 15[4], 16[5], 17[6], 18[7], 19[8]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data