5alpha-pregnan-3beta,20alpha-diol disulfate to etiocholanolone glucuronide

Numerator Metabolite

Structure of 5alpha-pregnan-3beta,20alpha-diol disulfate
Metabolite Accession: GCST90199838
Name: 5alpha-pregnan-3beta,20alpha-diol disulfate
Hmdb Id: HMDB0094650
Super Pathway: NA
Sub Pathway: NA
Inchikey: LSQGWMYMIHQKSA

Denominator Metabolite

Structure of etiocholanolone glucuronide
Metabolite Accession: GCST90199964
Name: etiocholanolone glucuronide
Hmdb Id: HMDB0004484
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs113017476

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
-0.532
Position:
31989359
SE (Ratio):
0.050
Effect Allele:
A
Z-score (Ratio):
-10.646
Reference Allele:
G
-log10(P):
-59.269
MAF:
0.035
Beta (Num):
-0.247
Novel Locus:
No
SE (Num):
0.042
Beta (Den):
0.285
SE (Den):
0.041
No CNV overlap
rQTL cluster:
149
Reaction Distance:
NA
Closest Genes:
MEMO1 DPY30 SPAST XDH SLC30A6

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis, Progesterone metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Androgen and Estrogen Metabolism.5[1], 6[2], 7[3]

Ratio Explanation:

This ratio compares downstream metabolites of progesterone and androgen pathways, potentially reflecting the balance between progestin and androgenic steroid metabolism.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No phenotype is provided, so no causal link between DPY30, the metabolite ratio, and a phenotype can be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data