pregnenediol disulfate (c21h34o8s2)* to DHEAS

Numerator Metabolite

Metabolite Accession: GCST90199840
Name: pregnenediol disulfate (c21h34o8s2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of dehydroepiandrosterone sulfate (dhea-s)
Metabolite Accession: GCST90199673
Name: dehydroepiandrosterone sulfate (dhea-s)
Hmdb Id: HMDB0001032
Super Pathway: NA
Sub Pathway: NA
Inchikey: CZWCKYRVOZZJNM

Associated Genomic Regions

Region: rs113354025

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.265
Position:
101625549
SE (Ratio):
0.026
Effect Allele:
T
Z-score (Ratio):
-10.191
Reference Allele:
C
-log10(P):
-54.483
MAF:
0.058
Beta (Num):
-0.200
Novel Locus:
No
SE (Num):
0.029
Beta (Den):
0.065
SE (Den):
0.029
No CNV overlap
rQTL cluster:
68
Reaction Distance:
NA
Closest Genes:
DNMBP ABCC2 CUTC COX15 ENTPD7

LLM Analysis

Numerator Metabolite Explanation:

Steroid metabolism, Progesterone metabolism

Denominator Metabolite Explanation:

Steroidogenesis, Adrenal steroid synthesis.5[1], 6[2], 7[3], 8[4], 9[5]

Ratio Explanation:

The ratio may reflect altered hepatic clearance of sulfated steroids due to genetic variation in the ABCC2 transporter, affecting pregnenediol disulfate and DHEAS levels.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Impaired ABCC2 function due to genetic variation could disrupt the transport of steroid sulfates like pregnenediol disulfate and DHEAS from the liver. This disruption can contribute to liver-related phenotypes such as elevated ALT, AST, and GGT, which are indicators of liver cell injury.4[1], 10[2], 11[3]

Phenotype Driver:

Gene-centric:ABCC2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data