pregnenediol disulfate (c21h34o8s2)* to androstenediol (3alpha, 17alpha) monosulfate (3)

Numerator Metabolite

Metabolite Accession: GCST90199840
Name: pregnenediol disulfate (c21h34o8s2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90199856
Name: androstenediol (3alpha, 17alpha) monosulfate (3)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs113354025

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.273
Position:
101625549
SE (Ratio):
0.027
Effect Allele:
T
Z-score (Ratio):
-10.189
Reference Allele:
C
-log10(P):
-54.469
MAF:
0.058
Beta (Num):
-0.200
Novel Locus:
No
SE (Num):
0.029
Beta (Den):
0.073
SE (Den):
0.029
No CNV overlap
rQTL cluster:
68
Reaction Distance:
NA
Closest Genes:
DNMBP ABCC2 CUTC COX15 ENTPD7

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
0.838
Position:
99075038
SE (Ratio):
0.034
Effect Allele:
C
Z-score (Ratio):
24.488
Reference Allele:
T
-log10(P):
-303.255
MAF:
0.035
Beta (Num):
-0.002
Novel Locus:
No
SE (Num):
0.037
Beta (Den):
-0.840
SE (Den):
0.037
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Androgen and Estrogen Metabolism

Denominator Metabolite Explanation:

Androgen and Estrogen Metabolism

Ratio Explanation:

This ratio reflects the balance between two sulfated steroid metabolites, potentially influenced by sulfotransferase and glucuronosyltransferase activity involved in steroid inactivation and elimination.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variations in UGT2B17 and UGT2B15 can alter the metabolism of androgens and estrogens, affecting their circulating levels. This dysregulation of steroid hormones is associated with disorders of lipoprotein metabolism, likely through the influence of sex steroids on lipid profiles.

Phenotype Driver:

Gene-centric:UGT2B17

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data