pregnenediol disulfate (c21h34o8s2)* to androstenediol (3beta,17beta) monosulfate (2)

Numerator Metabolite

Metabolite Accession: GCST90199840
Name: pregnenediol disulfate (c21h34o8s2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Associated Genomic Regions

Region: rs73079476

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.282
Position:
21343833
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
14.459
Reference Allele:
A
-log10(P):
-107.431
MAF:
0.156
Beta (Num):
0.165
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.117
SE (Den):
0.021
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Steroid hormone biosynthesis, Sulfation.6[1], 7[2]

Denominator Metabolite Explanation:

Steroid hormone biosynthesis, Sulfation.6[1], 8[2], 9[3]

Ratio Explanation:

The ratio likely reflects altered hepatic clearance of sulfated steroids due to impaired SLCO1B1 transporter function, which is known to handle steroid conjugates.10[1], 11[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Impaired SLCO1B1 function alters the clearance of its substrates, causing elevated bilirubin (TBil, MCH) and impacting steroid levels, which, along with its known role in statin transport, connects it to coronary atherosclerosis risk.12[1], 13[2], 14[3], 15[4], 16[5]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data