1-palmitoyl-2-linoleoyl-gpe (16:0/18:2) to 1-stearoyl-gpe (18:0)

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Metabolite Accession: GCST90199844
Name: 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Hmdb Id: HMDB0005322
Super Pathway: NA
Sub Pathway: NA
Inchikey: HBZNVZIRJWODIB

Denominator Metabolite

Structure of 1-stearoyl-gpe (18:0)
Metabolite Accession: GCST90199772
Name: 1-stearoyl-gpe (18:0)
Hmdb Id: HMDB0011130
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBYWOYAFBUOUFP

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.498
Position:
61588305
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
29.811
Reference Allele:
A
-log10(P):
-447.985
MAF:
0.344
Beta (Num):
0.424
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.074
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid Metabolism

Denominator Metabolite Explanation:

Glycerophospholipid Metabolism

Ratio Explanation:

The ratio reflects the balance of polyunsaturated versus saturated fatty acids in phosphatidylethanolamines, directly influenced by FADS1/FADS2 desaturase activity on fatty acid precursors.4[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1 gene variants alter desaturase activity, affecting the balance of pro- and anti-inflammatory lipid mediators.5[1], 6[2] This dysregulation is linked to phenotypes like valvular heart disease and cholelithiasis, where altered lipid metabolism and inflammation are key pathological factors.7[3], 8[4], 9[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data