1-palmitoyl-2-linoleoyl-gpe (16:0/18:2) to 1-arachidonoyl-gpc (20:4n6)*

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Metabolite Accession: GCST90199844
Name: 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Hmdb Id: HMDB0005322
Super Pathway: NA
Sub Pathway: NA
Inchikey: HBZNVZIRJWODIB

Denominator Metabolite

Structure of 1-arachidonoyl-gpc (20:4n6)*
Metabolite Accession: GCST90199788
Name: 1-arachidonoyl-gpc (20:4n6)*
Hmdb Id: HMDB0010395
Super Pathway: NA
Sub Pathway: NA
Inchikey: LAXQYRRMGGEGOH

Associated Genomic Regions

Region: rs174533

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.983
Position:
61549025
SE (Ratio):
0.025
Effect Allele:
A
Z-score (Ratio):
40.095
Reference Allele:
G
-log10(P):
-807.712
MAF:
0.339
Beta (Num):
0.422
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.561
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.5[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.6[1], 7[2]

Ratio Explanation:

The ratio reflects FADS enzyme activity, comparing the linoleic acid (18:2) precursor-containing GPE to the arachidonic acid (20:4) product-containing GPC.1[1], 4[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by a higher ratio, alters polyunsaturated fatty acid balance.8[1], 9[2], 10[3] This dysregulation of lipid metabolism is linked to an increased risk for disorders like pure hypercholesterolaemia and cholelithiasis, which have strong phenotypic associations.11[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data