1-palmitoyl-2-linoleoyl-gpe (16:0/18:2) to 1-stearoyl-2-docosahexaenoyl-gpc (18:0/22:6)

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Metabolite Accession: GCST90199844
Name: 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Hmdb Id: HMDB0005322
Super Pathway: NA
Sub Pathway: NA
Inchikey: HBZNVZIRJWODIB

Denominator Metabolite

Structure of 1-stearoyl-2-docosahexaenoyl-gpc (18:0/22:6)
Metabolite Accession: GCST90200046
Name: 1-stearoyl-2-docosahexaenoyl-gpc (18:0/22:6)
Hmdb Id: HMDB0008057
Super Pathway: NA
Sub Pathway: NA
Inchikey: FAUYAENFVCNTAL

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.671
Position:
61569830
SE (Ratio):
0.024
Effect Allele:
T
Z-score (Ratio):
28.212
Reference Allele:
C
-log10(P):
-401.526
MAF:
0.340
Beta (Num):
0.423
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.247
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

The ratio reflects the balance between glycerophosphoethanolamine and glycerophosphocholine lipids, influenced by fatty acid desaturase (FADS) activity, with FADS1 and FADS2 being key enzymes.1[1], 2[2], 4[3], 5[4]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in the FADS gene cluster, particularly FADS1 and FADS2, alters fatty acid metabolism, influencing the levels of specific phospholipids.3[1], 6[2], 7[3] This dysregulation is linked to various inflammatory and metabolic disorders, including cholelithiasis and type 2 diabetes, due to the role of these lipids in membrane structure and signaling.8[4], 9[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data