1-palmitoyl-2-linoleoyl-gpe (16:0/18:2) to 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Metabolite Accession: GCST90199844
Name: 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Hmdb Id: HMDB0005322
Super Pathway: NA
Sub Pathway: NA
Inchikey: HBZNVZIRJWODIB

Denominator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs10160784

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.200
Position:
75456055
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
8.914
Reference Allele:
T
-log10(P):
-42.157
MAF:
0.162
Beta (Num):
0.135
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
-0.065
SE (Den):
0.020
No CNV overlap
rQTL cluster:
56
Reaction Distance:
NA
Closest Genes:
MOGAT2 DGAT2 UVRAG MAP6 SERPINH1

Region: rs12928099

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Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.262
Position:
15150505
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-14.370
Reference Allele:
C
-log10(P):
-106.146
MAF:
0.291
Beta (Num):
-0.100
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.162
SE (Den):
0.017
No CNV overlap
rQTL cluster:
34
Reaction Distance:
NA
Closest Genes:
PDXDC1 NTAN1 RRN3 NPIPA1 NOMO1

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylethanolamine (PE) synthesis, Glycerophospholipid metabolism.8[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine (PC) metabolism.9[1], 10[2], 11[3]

Ratio Explanation:

The ratio reflects the balance between PE and PC species, potentially influenced by acyltransferase activity on different fatty acid substrates.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The MOGAT2/DGAT2 locus is linked to triglyceride and HDL metabolism.1[1], 2[2] Altered lipid metabolism, potentially influenced by these genes, is associated with gout, a phenotype linked to this locus. The ratio may reflect lipid compositional changes contributing to this association.

Phenotype Driver:

Gene-centric:MOGAT2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data