1-palmitoyl-2-linoleoyl-gpe (16:0/18:2) to 1-(1-enyl-palmitoyl)-2-arachidonoyl-gpc (p-16:0/20:4)*

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Metabolite Accession: GCST90199844
Name: 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Hmdb Id: HMDB0005322
Super Pathway: NA
Sub Pathway: NA
Inchikey: HBZNVZIRJWODIB

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-arachidonoyl-gpc (p-16:0/20:4)*
Metabolite Accession: GCST90200052
Name: 1-(1-enyl-palmitoyl)-2-arachidonoyl-gpc (p-16:0/20:4)*
Hmdb Id: HMDB0011220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IOYKZPNDXIIXLN

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.899
Position:
61588305
SE (Ratio):
0.026
Effect Allele:
G
Z-score (Ratio):
35.203
Reference Allele:
A
-log10(P):
-623.430
MAF:
0.344
Beta (Num):
0.424
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.475
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.5[1]

Denominator Metabolite Explanation:

Ether lipid metabolism.6[1]

Ratio Explanation:

This ratio reflects the conversion of linoleoyl-containing lipids to arachidonoyl-containing lipids, a process mediated by FADS1/FADS2 enzymes in polyunsaturated fatty acid metabolism.1[1], 7[2], 8[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter enzyme activity, impacting the ratio of linoleic to arachidonic acid.9[1], 10[2], 11[3] This balance is crucial for regulating inflammation and lipid profiles, influencing susceptibility to inflammatory bowel disease and hypercholesterolemia.2[4], 12[5], 13[6], 14[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data