1-palmitoyl-2-linoleoyl-gpe (16:0/18:2) to 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Metabolite Accession: GCST90199844
Name: 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Hmdb Id: HMDB0005322
Super Pathway: NA
Sub Pathway: NA
Inchikey: HBZNVZIRJWODIB

Denominator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Metabolite Accession: GCST90200054
Name: 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Hmdb Id: HMDB0005323
Super Pathway: NA
Sub Pathway: NA
Inchikey: DRIVXEVMDWCWLI

Associated Genomic Regions

Region: rs174528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.518
Position:
61543499
SE (Ratio):
0.014
Effect Allele:
C
Z-score (Ratio):
37.998
Reference Allele:
T
-log10(P):
-725.776
MAF:
0.370
Beta (Num):
0.392
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.126
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
MYRF TMEM258 FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid metabolism.3[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, arachidonic acid metabolism.4[1]

Ratio Explanation:

This ratio reflects the enzymatic efficiency of FADS1/FADS2 in converting linoleic acid (18:2) to arachidonic acid (20:4) within phosphatidylethanolamines.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters desaturase efficiency, reflected in the ratio, and is causally linked to disorders of lipoprotein metabolism and hypercholesterolemia.5[1], 6[2], 7[3], 8[4] This is supported by Mendelian Randomization and the role of these lipids in lipoprotein structure and function.9[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data