1-palmitoyl-2-linoleoyl-gpe (16:0/18:2) to 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Metabolite Accession: GCST90199844
Name: 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Hmdb Id: HMDB0005322
Super Pathway: NA
Sub Pathway: NA
Inchikey: HBZNVZIRJWODIB

Denominator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Metabolite Accession: GCST90200058
Name: 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Hmdb Id: HMDB0005779
Super Pathway: NA
Sub Pathway: NA
Inchikey: URPXXNCTXCOATD

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.712
Position:
61588305
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
29.088
Reference Allele:
A
-log10(P):
-426.646
MAF:
0.344
Beta (Num):
0.424
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.288
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism6[1]

Denominator Metabolite Explanation:

Plasmalogen synthesis, Glycerophospholipid metabolism7[1], 8[2]

Ratio Explanation:

This ratio reflects the balance between a common glycerophosphoethanolamine and a plasmalogen, with FADS gene activity influencing the abundance of unsaturated fatty acid chains.1[1], 9[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS cluster influence the levels of both metabolites.9[1] Altered levels of plasmalogens, the denominator, have been linked to benign and malignant colorectal neoplasms, potentially through modulation of oxidative stress and cell signaling.10[2], 11[3], 12[4], 13[5], 14[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data