1-palmitoyl-2-linoleoyl-gpe (16:0/18:2) to 1-stearoyl-2-docosahexaenoyl-gpe (18:0/22:6)*

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Metabolite Accession: GCST90199844
Name: 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Hmdb Id: HMDB0005322
Super Pathway: NA
Sub Pathway: NA
Inchikey: HBZNVZIRJWODIB

Denominator Metabolite

Structure of 1-stearoyl-2-docosahexaenoyl-gpe (18:0/22:6)*
Metabolite Accession: GCST90200065
Name: 1-stearoyl-2-docosahexaenoyl-gpe (18:0/22:6)*
Hmdb Id: HMDB0009012
Super Pathway: NA
Sub Pathway: NA
Inchikey: XYYHNDVKALDFHQ

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.496
Position:
61569830
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
28.483
Reference Allele:
C
-log10(P):
-409.210
MAF:
0.340
Beta (Num):
0.423
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.072
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, PUFA metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, PUFA metabolism.5[1], 4[2]

Ratio Explanation:

This ratio reflects FADS desaturase activity, comparing the incorporation of omega-6 linoleic acid versus omega-3 docosahexaenoic acid into phosphoethanolamines.1[1], 4[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS gene activity alters the balance of omega-6/omega-3 PUFAs incorporated into phospholipids.4[1] This shift impacts inflammatory responses and lipid profiles, plausibly contributing to the risk of inflammatory diseases (asthma, IBD) and lipoprotein disorders (hypercholesterolemia), which are associated phenotypes.6[2], 7[3], 8[4], 9[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data