1-palmitoyl-2-linoleoyl-gpe (16:0/18:2) to linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]*

Numerator Metabolite

Structure of 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Metabolite Accession: GCST90199844
Name: 1-palmitoyl-2-linoleoyl-gpe (16:0/18:2)
Hmdb Id: HMDB0005322
Super Pathway: NA
Sub Pathway: NA
Inchikey: HBZNVZIRJWODIB

Denominator Metabolite

Structure of linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]*
Metabolite Accession: GCST90200103
Name: linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]*
Hmdb Id: HMDB0007257
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRECEGQUDDMNAQ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.740
Position:
61588305
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
35.951
Reference Allele:
A
-log10(P):
-650.040
MAF:
0.344
Beta (Num):
0.424
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.316
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylethanolamine biosynthesis, Glycerophospholipid metabolism11[1], 12[2], 13[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, triacylglycerol metabolism12[1], 13[2]

Ratio Explanation:

The ratio reflects the conversion of linoleic acid to arachidonic acid, influenced by FADS1/FADS2 activity, impacting downstream inflammatory and signaling pathways.3[1], 8[2], 14[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity, indicated by the metabolite ratio, is associated with inflammatory conditions and cell signaling disruptions. The eQTL for TMEM258, linked to intestinal inflammation15[1], 16[2], and its MR association with benign colon neoplasms17[3], 18[4], 19[5], suggests a genetic predisposition to these conditions mediated by metabolic changes.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data