4-allylphenol sulfate to hydroxy-cmpf*

Numerator Metabolite

Structure of 4-allylphenol sulfate
Metabolite Accession: GCST90199847
Name: 4-allylphenol sulfate
Hmdb Id: HMDB0170765
Super Pathway: NA
Sub Pathway: NA
Inchikey: KFDHKOFCRYUXLA

Denominator Metabolite

Metabolite Accession: GCST90200154
Name: hydroxy-cmpf*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs1165152

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.196
Position:
25818766
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
-9.905
Reference Allele:
G
-log10(P):
-51.580
MAF:
0.444
Beta (Num):
-0.086
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.109
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Phenylsulfates.3[1], 4[2]

Denominator Metabolite Explanation:

Tryptophan metabolism, Fatty acid metabolism.5[1], 6[2]

Ratio Explanation:

The ratio likely reflects competition for or altered efficiency of renal clearance via the SLC17A4 transporter, affecting these structurally unrelated organic anions.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 variant likely alters its transport of organic anions, directly impacting serum levels of its substrates, including uric acid and creatinine.7[1], 8[2] This explains the strong PheWAS association with UA and sCr, and potentially influences hematological indices through overall kidney function.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data