4-allylphenol sulfate to 3-formylindole

Numerator Metabolite

Structure of 4-allylphenol sulfate
Metabolite Accession: GCST90199847
Name: 4-allylphenol sulfate
Hmdb Id: HMDB0170765
Super Pathway: NA
Sub Pathway: NA
Inchikey: KFDHKOFCRYUXLA

Denominator Metabolite

Structure of 3-formylindole
Metabolite Accession: GCST90200184
Name: 3-formylindole
Hmdb Id: HMDB29737
Super Pathway: NA
Sub Pathway: NA
Inchikey: OLNJUISKUQQNIM

Associated Genomic Regions

Region: rs9467618

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.211
Position:
25824809
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
9.294
Reference Allele:
C
-log10(P):
-45.660
MAF:
0.247
Beta (Num):
0.129
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.082
SE (Den):
0.017
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 SLC17A2 HIST1H2BA

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Phenylsulfate metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Tryptophan metabolism.7[1]

Ratio Explanation:

The ratio of 4-allylphenol sulfate to 3-formylindole may reflect altered xenobiotic and tryptophan metabolism, potentially influenced by SLC17A3's role in organic anion transport.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC17A3 function, affecting the transport of urate and other organic anions, likely influences uric acid levels. This dysregulation, potentially reflected in the metabolite ratio, is associated with variations in red blood cell count, pulse pressure, and body mass index.3[1], 8[2], 9[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:SLC17A3

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data