21-hydroxypregnenolone disulfate to xanthurenate

Numerator Metabolite

Structure of 21-hydroxypregnenolone disulfate
Metabolite Accession: GCST90199849
Name: 21-hydroxypregnenolone disulfate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBOVWLYQUCVTFA

Denominator Metabolite

Structure of xanthurenate
Metabolite Accession: GCST90199626
Name: xanthurenate
Hmdb Id: HMDB0000881
Super Pathway: NA
Sub Pathway: NA
Inchikey: FBZONXHGGPHHIY

Associated Genomic Regions

Region: rs2762353

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.269
Position:
25794431
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
12.622
Reference Allele:
G
-log10(P):
-82.430
MAF:
0.445
Beta (Num):
0.161
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.108
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Steroid hormone biosynthesis.5[1]

Denominator Metabolite Explanation:

Tryptophan metabolism.6[1], 7[2]

Ratio Explanation:

The SLC17A4 transporter may influence the excretion of both metabolites, although they are from unrelated pathways. Evidence for this interaction is weak.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 gene's role as a urate exporter directly impacts serum uric acid levels, a key associated phenotype.1[1], 2[2], 8[3], 4[4] Its influence on red blood cell indices may be mediated through its secondary role in thyroid hormone transport and erythropoiesis.9[5], 10[6], 11[7], 12[8]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data