21-hydroxypregnenolone disulfate to 5alpha-pregnan-3beta,20beta-diol monosulfate (1)

Numerator Metabolite

Structure of 21-hydroxypregnenolone disulfate
Metabolite Accession: GCST90199849
Name: 21-hydroxypregnenolone disulfate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBOVWLYQUCVTFA

Denominator Metabolite

Structure of 5alpha-pregnan-3beta,20beta-diol monosulfate (1)
Metabolite Accession: GCST90199853
Name: 5alpha-pregnan-3beta,20beta-diol monosulfate (1)
Hmdb Id: HMDB0240580
Super Pathway: NA
Sub Pathway: NA
Inchikey: NOGKXXMAHGCQBS

Associated Genomic Regions

Region: rs148982377

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
0.381
Position:
99075038
SE (Ratio):
0.040
Effect Allele:
C
Z-score (Ratio):
9.468
Reference Allele:
T
-log10(P):
-47.305
MAF:
0.034
Beta (Num):
0.081
Novel Locus:
No
SE (Num):
0.040
Beta (Den):
-0.300
SE (Den):
0.043
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Steroid hormone biosynthesis.2[1], 3[2]

Denominator Metabolite Explanation:

Steroid hormone metabolism.4[1], 3[2]

Ratio Explanation:

This ratio reflects the balance between a sulfated steroid precursor (21-hydroxypregnenolone disulfate) and a downstream metabolite (5alpha-pregnan-3beta,20beta-diol monosulfate), potentially influenced by sulfotransferase activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation near the GAL3ST4 gene may alter steroid metabolism, reflected by the ratio. Given that steroid levels are linked to inflammation and metabolic regulation, this could influence phenotypes like C-reactive protein, white blood cell count, uric acid, and BMI.5[1], 6[2], 7[3]

Phenotype Driver:

Metabolite-centric[both]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data