21-hydroxypregnenolone disulfate to androstenediol (3alpha, 17alpha) monosulfate (3)

Numerator Metabolite

Structure of 21-hydroxypregnenolone disulfate
Metabolite Accession: GCST90199849
Name: 21-hydroxypregnenolone disulfate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBOVWLYQUCVTFA

Denominator Metabolite

Metabolite Accession: GCST90199856
Name: androstenediol (3alpha, 17alpha) monosulfate (3)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs148982377

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
7
Beta (Ratio):
0.921
Position:
99075038
SE (Ratio):
0.039
Effect Allele:
C
Z-score (Ratio):
23.853
Reference Allele:
T
-log10(P):
-287.877
MAF:
0.034
Beta (Num):
0.081
Novel Locus:
No
SE (Num):
0.040
Beta (Den):
-0.840
SE (Den):
0.037
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis, Pregnenolone Metabolism4[1], 5[2]

Denominator Metabolite Explanation:

Steroidogenesis, Androgen Metabolism6[1], 7[2], 8[3]

Ratio Explanation:

The ratio of 21-hydroxypregnenolone, an early steroid precursor, to the androgen androstenediol may reflect shifts in steroid synthesis pathways influenced by sulfation.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered steroid hormone balance, potentially influenced by GAL3ST4-mediated sulfation, is linked to systemic metabolic and inflammatory phenotypes like BMI, C-reactive protein, and white blood cell count.

Phenotype Driver:

Gene-centric:GAL3ST4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data