21-hydroxypregnenolone disulfate to glycine conjugate of c10h14o2 (1)*

Numerator Metabolite

Structure of 21-hydroxypregnenolone disulfate
Metabolite Accession: GCST90199849
Name: 21-hydroxypregnenolone disulfate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBOVWLYQUCVTFA

Denominator Metabolite

Metabolite Accession: GCST90200175
Name: glycine conjugate of c10h14o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs12132488

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.390
Position:
47389613
SE (Ratio):
0.032
Effect Allele:
T
Z-score (Ratio):
-12.022
Reference Allele:
C
-log10(P):
-74.988
MAF:
0.128
Beta (Num):
-0.189
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
0.201
SE (Den):
0.023
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis.6[1], 7[2]

Denominator Metabolite Explanation:

Xenobiotic Metabolism.8[1], 9[2]

Ratio Explanation:

The ratio likely reflects the balance between steroid hormone biosynthesis (numerator) and detoxification of xenobiotics (denominator), potentially linked by FAAH-mediated signaling which can influence steroidogenesis.10[1], 11[2], 12[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data