21-hydroxypregnenolone disulfate to x-21470

Numerator Metabolite

Structure of 21-hydroxypregnenolone disulfate
Metabolite Accession: GCST90199849
Name: 21-hydroxypregnenolone disulfate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBOVWLYQUCVTFA

Denominator Metabolite

Metabolite Accession: GCST90200590
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs11211402

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.199
Position:
47392054
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
-10.352
Reference Allele:
T
-log10(P):
-56.156
MAF:
0.123
Beta (Num):
-0.190
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
0.009
SE (Den):
0.024
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

Region: rs34196306

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.181
Position:
27425644
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
-8.127
Reference Allele:
G
-log10(P):
-35.362
MAF:
0.087
Beta (Num):
-0.059
Novel Locus:
Yes ✔️
SE (Num):
0.026
Beta (Den):
0.121
SE (Den):
0.028
No CNV overlap
rQTL cluster:
110
Reaction Distance:
NA
Closest Genes:
ZNF184 ZNF391 POM121L2 PRSS16 HIST1H2AH

Region: rs3131071

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.163
Position:
28906922
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
-7.563
Reference Allele:
C
-log10(P):
-30.869
MAF:
0.093
Beta (Num):
-0.033
Novel Locus:
Yes ✔️
SE (Num):
0.025
Beta (Den):
0.130
SE (Den):
0.027
No CNV overlap
rQTL cluster:
110
Reaction Distance:
NA
Closest Genes:
C6orf100 TRIM27 ZNF311 OR2W1 OR2B3

Region: rs2517601

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.162
Position:
30074072
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
-8.076
Reference Allele:
G
-log10(P):
-34.944
MAF:
0.111
Beta (Num):
-0.049
Novel Locus:
Yes ✔️
SE (Num):
0.023
Beta (Den):
0.113
SE (Den):
0.025
No CNV overlap
rQTL cluster:
110
Reaction Distance:
NA
Closest Genes:
TRIM31 TRIM40 RNF39 PPP1R11 ZNRD1

LLM Analysis

Not available.

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data