21-hydroxypregnenolone disulfate to x-24544

Numerator Metabolite

Structure of 21-hydroxypregnenolone disulfate
Metabolite Accession: GCST90199849
Name: 21-hydroxypregnenolone disulfate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBOVWLYQUCVTFA

Denominator Metabolite

Metabolite Accession: GCST90200636
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs4149083

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Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
0.194
Position:
21380630
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
12.214
Reference Allele:
A
-log10(P):
-77.328
MAF:
0.166
Beta (Num):
0.206
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.013
SE (Den):
0.019
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 SLCO1A2 RP11-125O5.2 IAPP SLCO1B7

Region: rs2817188

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.163
Position:
25807603
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
13.645
Reference Allele:
G
-log10(P):
-95.941
MAF:
0.445
Beta (Num):
0.161
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.002
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

Region: rs34613987

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.161
Position:
27433029
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
-8.304
Reference Allele:
C
-log10(P):
-36.836
MAF:
0.104
Beta (Num):
-0.077
Novel Locus:
Yes ✔️
SE (Num):
0.024
Beta (Den):
0.084
SE (Den):
0.023
No CNV overlap
rQTL cluster:
110
Reaction Distance:
NA
Closest Genes:
ZNF184 ZNF391 POM121L2 PRSS16 HIST1H2AH

LLM Analysis

Not available.

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data