5alpha-androstan-3alpha,17alpha-diol monosulfate to androsterone glucuronide

Numerator Metabolite

Structure of 5alpha-androstan-3alpha,17alpha-diol monosulfate
Metabolite Accession: GCST90199850
Name: 5alpha-androstan-3alpha,17alpha-diol monosulfate
Hmdb Id: HMDB0000412
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBMYJHIOYJEBSB

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs62317882

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Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
0.327
Position:
69355709
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
16.012
Reference Allele:
C
-log10(P):
-131.200
MAF:
0.384
Beta (Num):
0.271
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.057
SE (Den):
0.014
No CNV overlap
rQTL cluster:
124
Reaction Distance:
NA
Closest Genes:
TMPRSS11E UGT2B17 YTHDC1 UGT2B15 TMPRSS11B

LLM Analysis

Numerator Metabolite Explanation:

Androgen metabolism, Steroid sulfation.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Androgen metabolism, Steroid glucuronidation.1[1], 6[2], 7[3], 8[4]

Ratio Explanation:

The ratio indicates the balance between sulfation and glucuronidation of androgens, a process influenced by the activity of UGT2B15 and UGT2B17 enzymes.1[1], 8[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in UGT2B17 and UGT2B15 alters androgen metabolism.1[1], 2[2] This hormonal imbalance may influence cell proliferation in the colon, impact kidney stone formation, and affect hepatic function, which is reflected in altered lipid and liver enzyme levels.9[3], 10[4], 11[5], 12[6], 13[7], 14[8]

Phenotype Driver:

Gene-centric:UGT2B17/UGT2B15

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data