androstenediol (3beta,17beta) disulfate (2) to xanthurenate

Numerator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (2)
Metabolite Accession: GCST90199851
Name: androstenediol (3beta,17beta) disulfate (2)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Denominator Metabolite

Structure of xanthurenate
Metabolite Accession: GCST90199626
Name: xanthurenate
Hmdb Id: HMDB0000881
Super Pathway: NA
Sub Pathway: NA
Inchikey: FBZONXHGGPHHIY

Associated Genomic Regions

Region: rs1165154

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.198
Position:
25817216
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
9.619
Reference Allele:
C
-log10(P):
-48.758
MAF:
0.445
Beta (Num):
0.091
Novel Locus:
No
SE (Num):
0.014
Beta (Den):
-0.107
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Steroid hormone biosynthesis.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Tryptophan metabolism.9[1], 10[2], 11[3]

Ratio Explanation:

The ratio likely indicates a disruption in transport homeostasis, as SLC17A4, a urate and organic anion transporter, may influence substrates from separate pathways.3[1], 5[2], 9[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC17A4 function due to a genetic variant likely affects its transport of urate, a key substrate, directly influencing serum uric acid and creatinine levels.12[1], 5[2], 13[3] The association with red blood cell indices (MCH, MCHC, Hb) might be secondary to changes in renal function or overall metabolic state.14[4]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data