androstenediol (3beta,17beta) disulfate (2) to DHEAS

Numerator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (2)
Metabolite Accession: GCST90199851
Name: androstenediol (3beta,17beta) disulfate (2)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Denominator Metabolite

Structure of dehydroepiandrosterone sulfate (dhea-s)
Metabolite Accession: GCST90199673
Name: dehydroepiandrosterone sulfate (dhea-s)
Hmdb Id: HMDB0001032
Super Pathway: NA
Sub Pathway: NA
Inchikey: CZWCKYRVOZZJNM

Associated Genomic Regions

Region: rs113354025

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.199
Position:
101625549
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
-8.854
Reference Allele:
C
-log10(P):
-41.617
MAF:
0.059
Beta (Num):
-0.134
Novel Locus:
Yes ✔️
SE (Num):
0.029
Beta (Den):
0.065
SE (Den):
0.029
No CNV overlap
rQTL cluster:
68
Reaction Distance:
NA
Closest Genes:
DNMBP ABCC2 CUTC COX15 ENTPD7

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
0.439
Position:
99075038
SE (Ratio):
0.029
Effect Allele:
C
Z-score (Ratio):
15.248
Reference Allele:
T
-log10(P):
-119.203
MAF:
0.035
Beta (Num):
0.015
Novel Locus:
No
SE (Num):
0.038
Beta (Den):
-0.423
SE (Den):
0.037
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Steroid sulfation4[1]

Denominator Metabolite Explanation:

Steroidogenesis, DHEA Metabolism5[1], 6[2], 7[3], 8[4], 9[5]

Ratio Explanation:

The ratio reflects the balance between sulfated androstenediol and DHEAS, both part of steroid hormone metabolism, potentially influenced by ABCC2-mediated transport of sulfated steroids.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered ABCC2 function may impact the transport of sulfated steroids, influencing downstream inflammatory and metabolic phenotypes including levels of C-reactive protein and liver enzymes (AST, GGT).10[1], 11[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:ABCC2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data