androstenediol (3beta,17beta) disulfate (2) to pregnenediol sulfate (c21h34o5s)*

Numerator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (2)
Metabolite Accession: GCST90199851
Name: androstenediol (3beta,17beta) disulfate (2)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Denominator Metabolite

Structure of pregnenediol sulfate (c21h34o5s)*
Metabolite Accession: GCST90199861
Name: pregnenediol sulfate (c21h34o5s)*
Hmdb Id: HMDB0000774
Super Pathway: NA
Sub Pathway: NA
Inchikey: DIJBBUIOWGGQOP

Associated Genomic Regions

Region: rs3756669

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.248
Position:
35965970
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
-15.785
Reference Allele:
A
-log10(P):
-127.572
MAF:
0.145
Beta (Num):
0.014
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.262
SE (Den):
0.018
No CNV overlap
rQTL cluster:
116
Reaction Distance:
NA
Closest Genes:
UGT3A1 CAPSL UGT3A2 IL7R LMBRD2

LLM Analysis

Numerator Metabolite Explanation:

Androgen Metabolism, Steroid Sulfation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Steroidogenesis, Steroid Sulfation.7[1], 8[2], 9[3]

Ratio Explanation:

This ratio may reflect the balance between androgen production and upstream steroid precursors, influenced by the activity of competing conjugation enzymes like UGT3A1.4[1], 10[2], 11[3], 12[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No associated phenotype data is provided, so a causal link between the UGT3A1 variant, the steroid ratio, and a clinical outcome cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data