androstenediol (3beta,17beta) disulfate (2) to 16a-hydroxy dhea 3-sulfate

Numerator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (2)
Metabolite Accession: GCST90199851
Name: androstenediol (3beta,17beta) disulfate (2)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Denominator Metabolite

Structure of 16a-hydroxy dhea 3-sulfate
Metabolite Accession: GCST90199863
Name: 16a-hydroxy dhea 3-sulfate
Hmdb Id: HMDB0062544
Super Pathway: NA
Sub Pathway: NA
Inchikey: ALBNSVAJDFJRKQ

Associated Genomic Regions

Region: rs10128455

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.140
Position:
96851353
SE (Ratio):
0.013
Effect Allele:
C
Z-score (Ratio):
11.005
Reference Allele:
T
-log10(P):
-63.183
MAF:
0.478
Beta (Num):
0.032
Novel Locus:
No
SE (Num):
0.014
Beta (Den):
-0.108
SE (Den):
0.015
No CNV overlap
rQTL cluster:
71
Reaction Distance:
NA
Closest Genes:
CYP2C8 CYP2C9 C10orf129 PDLIM1 SORBS1

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-1.029
Position:
99075038
SE (Ratio):
0.033
Effect Allele:
C
Z-score (Ratio):
-30.807
Reference Allele:
T
-log10(P):
-478.175
MAF:
0.035
Beta (Num):
0.015
Novel Locus:
No
SE (Num):
0.038
Beta (Den):
1.044
SE (Den):
0.039
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism.9[1], 10[2]

Denominator Metabolite Explanation:

Steroidogenesis, DHEA metabolism.11[1], 12[2], 13[3]

Ratio Explanation:

The ratio reflects the balance between different steroid hormone metabolism pathways, where androstenediol is an androgen and estrogen precursor and 16a-hydroxy DHEA is a DHEA metabolite.11[1], 9[2], 10[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

CYP2C9 gene variants can alter steroid metabolism, influencing the levels of androgens and their metabolites.1[1], 14[2], 3[3], 4[4] This altered steroid profile, along with CYP2C9's role in drug and xenobiotic metabolism, may contribute to variations in BMI, C-reactive protein, and white blood cell count.15[5], 16[6], 17[7], 18[8], 19[9], 20[10], 21[11], 22[12], 23[13], 24[14], 25[15], 26[16]

Phenotype Driver:

Gene-centric:CYP2C9

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data