androstenediol (3beta,17beta) disulfate (2) to n-acetylphenylalanine

Numerator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (2)
Metabolite Accession: GCST90199851
Name: androstenediol (3beta,17beta) disulfate (2)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Denominator Metabolite

Structure of n-acetylphenylalanine
Metabolite Accession: GCST90200677
Name: n-acetylphenylalanine
Hmdb Id: HMDB0000512
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBQJSKKFNMDLON

Associated Genomic Regions

Region: rs1177442

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.238
Position:
25809069
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
11.878
Reference Allele:
G
-log10(P):
-73.251
MAF:
0.445
Beta (Num):
0.091
Novel Locus:
No
SE (Num):
0.014
Beta (Den):
-0.148
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Steroid hormone biosynthesis.8[1], 9[2], 10[3], 11[4], 12[5]

Denominator Metabolite Explanation:

Phenylalanine metabolism.13[1], 14[2], 15[3], 16[4]

Ratio Explanation:

The ratio may reflect altered transport activity by SLC17A4, which influences urate levels (a phenotype), but a direct transport relationship with either metabolite is unconfirmed.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC17A4 function may alter urate excretion, leading to hyperuricemia and affecting red blood cell indices.4[1], 17[2], 18[3] Androgens are known to influence erythropoiesis, providing a potential link between the numerator and hematological traits.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data