5alpha-pregnan-3beta,20beta-diol monosulfate (1) to androsterone glucuronide

Numerator Metabolite

Structure of 5alpha-pregnan-3beta,20beta-diol monosulfate (1)
Metabolite Accession: GCST90199853
Name: 5alpha-pregnan-3beta,20beta-diol monosulfate (1)
Hmdb Id: HMDB0240580
Super Pathway: NA
Sub Pathway: NA
Inchikey: NOGKXXMAHGCQBS

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs62317882

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Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
0.138
Position:
69355709
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
7.759
Reference Allele:
C
-log10(P):
-32.389
MAF:
0.363
Beta (Num):
0.081
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
-0.057
SE (Den):
0.014
No CNV overlap
rQTL cluster:
124
Reaction Distance:
NA
Closest Genes:
TMPRSS11E UGT2B17 YTHDC1 UGT2B15 TMPRSS11B

LLM Analysis

Numerator Metabolite Explanation:

Progestin steroid metabolism, Sulfation.8[1], 9[2]

Denominator Metabolite Explanation:

Androgen metabolism, Glucuronidation.10[1], 4[2], 11[3]

Ratio Explanation:

The ratio reflects steroid metabolism, comparing a sulfated progesterone derivative to a glucuronidated androgen. Elevated ratios may suggest decreased UGT2B15/UGT2B17 glucuronidation activity.2[1], 4[2], 5[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

UGT2B15/UGT2B17 gene variations alter steroid hormone glucuronidation, affecting androgen and cholesterol levels. This dysregulation of steroid metabolism is associated with an increased risk for disorders of lipoprotein metabolism and benign colorectal neoplasms.12[1], 13[2], 14[3], 15[4]

Phenotype Driver:

Gene-centric:UGT2B17/UGT2B15

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data