androstenediol (3alpha, 17alpha) monosulfate (3) to DHEAS

Numerator Metabolite

Metabolite Accession: GCST90199856
Name: androstenediol (3alpha, 17alpha) monosulfate (3)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of dehydroepiandrosterone sulfate (dhea-s)
Metabolite Accession: GCST90199673
Name: dehydroepiandrosterone sulfate (dhea-s)
Hmdb Id: HMDB0001032
Super Pathway: NA
Sub Pathway: NA
Inchikey: CZWCKYRVOZZJNM

Associated Genomic Regions

Region: rs146523885;rs2278919

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
0.195
Position:
69362690
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
15.295
Reference Allele:
G
-log10(P):
-119.930
MAF:
0.362
Beta (Num):
0.191
Novel Locus:
No
SE (Num):
0.014
Beta (Den):
-0.004
SE (Den):
0.015
No CNV overlap
rQTL cluster:
124
Reaction Distance:
NA
Closest Genes:
TMPRSS11E UGT2B17 YTHDC1 UGT2B15 TMPRSS11B

LLM Analysis

Numerator Metabolite Explanation:

Androgen and Estrogen Metabolism

Denominator Metabolite Explanation:

Androgen and Estrogen Metabolism.4[1]

Ratio Explanation:

This ratio reflects the balance between sulfation and glucuronidation of DHEA and its metabolites.4[1] The UGT2B enzymes act on these steroids, influencing their levels.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered UGT2B17/UGT2B15 activity changes androgen levels, reflected in the ratio. This dysregulation may impact lipid metabolism, and is associated with benign neoplasms of the colon and rectum, and kidney stone formation.5[1], 6[2], 7[3]

Phenotype Driver:

Gene-centric:UGT2B17/UGT2B15

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data