androstenediol (3alpha, 17alpha) monosulfate (3) to pregnenediol sulfate (c21h34o5s)*

Numerator Metabolite

Metabolite Accession: GCST90199856
Name: androstenediol (3alpha, 17alpha) monosulfate (3)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of pregnenediol sulfate (c21h34o5s)*
Metabolite Accession: GCST90199861
Name: pregnenediol sulfate (c21h34o5s)*
Hmdb Id: HMDB0000774
Super Pathway: NA
Sub Pathway: NA
Inchikey: DIJBBUIOWGGQOP

Associated Genomic Regions

Region: rs148982377

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-0.870
Position:
99075038
SE (Ratio):
0.036
Effect Allele:
C
Z-score (Ratio):
-24.385
Reference Allele:
T
-log10(P):
-300.746
MAF:
0.033
Beta (Num):
-0.840
Novel Locus:
No
SE (Num):
0.037
Beta (Den):
0.030
SE (Den):
0.036
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Steroid hormone biosynthesis

Denominator Metabolite Explanation:

Steroid hormone biosynthesis

Ratio Explanation:

This ratio may represent the balance between different steroidogenesis branches, from pregnenolone-derived compounds to androgens, influenced by the activity of steroid-conjugating enzymes like UGT2B15.4[1], 5[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variation in steroid-conjugating genes like UGT2B15 can alter the balance of circulating androgens, reflected by the ratio. This hormonal shift subsequently influences hepatic lipid regulation, leading to hypercholesterolemia and associated dyslipidemias, which are known to be affected by steroid levels.6[1], 7[2], 8[3]

Phenotype Driver:

Metabolite-centric[both]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data