androstenediol (3alpha, 17alpha) monosulfate (3) to glyco-beta-muricholate**

Numerator Metabolite

Metabolite Accession: GCST90199856
Name: androstenediol (3alpha, 17alpha) monosulfate (3)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200179
Name: glyco-beta-muricholate**
Hmdb Id: HMDB0341323
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs148982377

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-1.729
Position:
99075038
SE (Ratio):
0.062
Effect Allele:
C
Z-score (Ratio):
-27.923
Reference Allele:
T
-log10(P):
-393.401
MAF:
0.033
Beta (Num):
-0.840
Novel Locus:
No
SE (Num):
0.037
Beta (Den):
0.889
SE (Den):
0.043
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Androgen and Estrogen Metabolism.5[1], 6[2], 7[3], 8[4], 9[5]

Denominator Metabolite Explanation:

Bile Acid Biosynthesis.10[1], 11[2], 12[3], 13[4], 14[5]

Ratio Explanation:

This ratio may reflect the activity of sulfotransferase GAL3ST4 on androstenediol, contrasting steroid hormone metabolism with bile acid synthesis.1[1], 15[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation near GAL3ST4 may alter sulfation activity, affecting the balance between steroid and bile acid pathways.1[1], 16[2] This shift, reflected by the ratio, could influence systemic inflammation (CRP, WBC) and metabolic traits (BMI, Uric Acid) potentially mediated by bile acid signaling.17[3], 18[4], 19[5], 20[6], 21[7]

Phenotype Driver:

Metabolite-centric[glyco-beta-muricholate]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data