5alpha-androstan-3alpha,17beta-diol monosulfate (1) to glyco-beta-muricholate**

Numerator Metabolite

Metabolite Accession: GCST90199858
Name: 5alpha-androstan-3alpha,17beta-diol monosulfate (1)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200179
Name: glyco-beta-muricholate**
Hmdb Id: HMDB0341323
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
-2.229
Position:
99075038
SE (Ratio):
0.072
Effect Allele:
C
Z-score (Ratio):
-31.000
Reference Allele:
T
-log10(P):
-484.146
MAF:
0.023
Beta (Num):
-1.340
Novel Locus:
No
SE (Num):
0.049
Beta (Den):
0.889
SE (Den):
0.043
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Androgen metabolism, Steroid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Bile acid biosynthesis.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio compares a sulfated androgen metabolite to a conjugated bile acid, reflecting the balance between steroid hormone and bile acid metabolism pathways.5[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered ATP5J2 function may impact cellular energy, shifting the balance of steroid and bile acid metabolism. This metabolic dysregulation, also linked to obesity, could contribute to changes in BMI, inflammatory markers (WBC, CRP), and uric acid levels.10[1], 11[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:[ATP5J2]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data