andro steroid monosulfate c19h28o6s (1)* to 3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-cmpfp)**

Numerator Metabolite

Structure of andro steroid monosulfate c19h28o6s (1)*
Metabolite Accession: GCST90199860
Name: andro steroid monosulfate c19h28o6s (1)*
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Denominator Metabolite

Structure of 3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-cmpfp)**
Metabolite Accession: GCST90200172
Name: 3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-cmpfp)**
Hmdb Id: HMDB0061643
Super Pathway: NA
Sub Pathway: NA
Inchikey: RIJDKRLRDVBUHJ

Associated Genomic Regions

Region: rs2071426

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.346
Position:
96828323
SE (Ratio):
0.025
Effect Allele:
C
Z-score (Ratio):
-14.049
Reference Allele:
T
-log10(P):
-101.557
MAF:
0.278
Beta (Num):
-0.146
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
0.200
SE (Den):
0.017
No CNV overlap
rQTL cluster:
71
Reaction Distance:
NA
Closest Genes:
CYP2C8 CYP2C9 C10orf129 PDLIM1 CYP2C19

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid metabolism.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio may reflect a balance between endogenous steroid hormone metabolism and the processing of furanoid fatty acids, potentially modulated by CYP2C enzymes.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered CYP2C gene activity could impact steroid hormone levels, which have been associated with glaucoma.11[1], 12[2], 13[3] This metabolic ratio might represent a biomarker for this altered state, linking the gene to the phenotype.

Phenotype Driver:

Gene-centric:CYP2C9

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data