andro steroid monosulfate c19h28o6s (1)* to androsterone sulfate

Numerator Metabolite

Structure of andro steroid monosulfate c19h28o6s (1)*
Metabolite Accession: GCST90199860
Name: andro steroid monosulfate c19h28o6s (1)*
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Denominator Metabolite

Structure of androsterone sulfate
Metabolite Accession: GCST90200674
Name: androsterone sulfate
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
2.332
Position:
99075038
SE (Ratio):
0.056
Effect Allele:
C
Z-score (Ratio):
41.679
Reference Allele:
T
-log10(P):
-872.528
MAF:
0.036
Beta (Num):
0.829
Novel Locus:
No
SE (Num):
0.041
Beta (Den):
-1.504
SE (Den):
0.038
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

Region: rs34183059

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
0.306
Position:
100079429
SE (Ratio):
0.029
Effect Allele:
G
Z-score (Ratio):
10.508
Reference Allele:
A
-log10(P):
-57.793
MAF:
0.164
Beta (Num):
0.131
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
-0.175
SE (Den):
0.020
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
NYAP1 TSC22D4 C7orf61 PPP1R35 MEPCE

LLM Analysis

Numerator Metabolite Explanation:

Androgen and Estrogen Metabolism.6[1], 7[2]

Denominator Metabolite Explanation:

Androgen and Estrogen Metabolism.8[1], 6[2]

Ratio Explanation:

The ratio likely reflects altered steroid metabolism, possibly modulated by mitochondrial function, but the specific role of andro steroid monosulfate c19h28o6s (1) is unclear.9[1], 10[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

ZNF394 expression is noted in the adrenal gland, a primary site of steroid metabolism.11[1] Altered steroid metabolism, potentially influenced by mitochondrial regulators like PTCD1, may affect androgen levels, which are linked to BMI, MCHC, MCH, and inflammatory markers like CRP and WBC count.12[2], 13[3], 14[4], 15[5], 16[6], 17[7]

Phenotype Driver:

Metabolite-centric[both]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data