andro steroid monosulfate c19h28o6s (1)* to androsterone glucuronide

Numerator Metabolite

Structure of andro steroid monosulfate c19h28o6s (1)*
Metabolite Accession: GCST90199860
Name: andro steroid monosulfate c19h28o6s (1)*
Hmdb Id: HMDB0002759
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
1.020
Position:
99075038
SE (Ratio):
0.046
Effect Allele:
C
Z-score (Ratio):
21.966
Reference Allele:
T
-log10(P):
-244.579
MAF:
0.036
Beta (Num):
0.829
Novel Locus:
No
SE (Num):
0.041
Beta (Den):
-0.191
SE (Den):
0.037
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Androgen metabolism, steroid sulfation.8[1], 9[2], 10[3], 11[4], 12[5]

Denominator Metabolite Explanation:

Androgen metabolism, steroid glucuronidation.13[1], 14[2], 15[3], 8[4], 16[5]

Ratio Explanation:

The ratio reflects competing pathways of androgen elimination, sulfation versus glucuronidation. An elevated ratio may suggest a preference for sulfation of androsterone.8[1]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in the sulfotransferase gene *GAL3ST4* could alter steroid sulfation, affecting the androsterone sulfate/glucuronide ratio.1[1], 2[2] This hormonal imbalance may contribute to inflammatory (CRP, WBC) and metabolic (BMI, UA) phenotypes.17[3], 18[4], 19[5], 20[6], 21[7], 22[8], 23[9], 24[10], 25[11], 26[12]

Phenotype Driver:

Gene-centric:GAL3ST4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data