pregnenediol sulfate (c21h34o5s)* to DHEAS

Numerator Metabolite

Structure of pregnenediol sulfate (c21h34o5s)*
Metabolite Accession: GCST90199861
Name: pregnenediol sulfate (c21h34o5s)*
Hmdb Id: HMDB0000774
Super Pathway: NA
Sub Pathway: NA
Inchikey: DIJBBUIOWGGQOP

Denominator Metabolite

Structure of dehydroepiandrosterone sulfate (dhea-s)
Metabolite Accession: GCST90199673
Name: dehydroepiandrosterone sulfate (dhea-s)
Hmdb Id: HMDB0001032
Super Pathway: NA
Sub Pathway: NA
Inchikey: CZWCKYRVOZZJNM

Associated Genomic Regions

Region: rs743575

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.098
Position:
104594906
SE (Ratio):
0.010
Effect Allele:
G
Z-score (Ratio):
9.723
Reference Allele:
T
-log10(P):
-49.777
MAF:
0.289
Beta (Num):
0.044
Novel Locus:
Yes ✔️
SE (Num):
0.014
Beta (Den):
-0.054
SE (Den):
0.015
No CNV overlap
rQTL cluster:
66
Reaction Distance:
4.0
Closest Genes:
CYP17A1 WBP1L C10orf32 C10orf32-ASMT AS3MT

Region: rs12659258

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.233
Position:
35970215
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
17.884
Reference Allele:
G
-log10(P):
-163.040
MAF:
0.145
Beta (Num):
0.262
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
0.030
SE (Den):
0.019
No CNV overlap
rQTL cluster:
116
Reaction Distance:
4.0
Closest Genes:
UGT3A1 CAPSL UGT3A2 IL7R LMBRD2

Region: rs148982377

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Clumped rQTL variant

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SNP Summary

Chr:
7
Beta (Ratio):
0.454
Position:
99075038
SE (Ratio):
0.025
Effect Allele:
C
Z-score (Ratio):
17.984
Reference Allele:
T
-log10(P):
-164.823
MAF:
0.034
Beta (Num):
0.030
Novel Locus:
No
SE (Num):
0.036
Beta (Den):
-0.423
SE (Den):
0.037
No CNV overlap
rQTL cluster:
90
Reaction Distance:
4.0
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Steroid hormone biosynthesis4[1]

Denominator Metabolite Explanation:

Steroid hormone biosynthesis5[1], 6[2], 7[3], 8[4]

Ratio Explanation:

The ratio may reflect the balance between pregnenolone metabolism and DHEA sulfation.5[1], 9[2], 4[3] UGT3A1's role is not directly established for these specific metabolites.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The UGT3A1 gene's function in metabolizing and eliminating substances could influence inflammatory and metabolic phenotypes like C-reactive protein and neutrophil counts.2[1], 10[2] While UGT3A1 is linked to uric acid metabolism, its direct role in the observed phenotypes through this specific ratio is not established.11[3], 12[4]

Phenotype Driver:

Gene-centric:UGT3A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data