16a-hydroxy dhea 3-sulfate to 3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-cmpfp)**

Numerator Metabolite

Structure of 16a-hydroxy dhea 3-sulfate
Metabolite Accession: GCST90199863
Name: 16a-hydroxy dhea 3-sulfate
Hmdb Id: HMDB0062544
Super Pathway: NA
Sub Pathway: NA
Inchikey: ALBNSVAJDFJRKQ

Denominator Metabolite

Structure of 3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-cmpfp)**
Metabolite Accession: GCST90200172
Name: 3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-cmpfp)**
Hmdb Id: HMDB0061643
Super Pathway: NA
Sub Pathway: NA
Inchikey: RIJDKRLRDVBUHJ

Associated Genomic Regions

Region: rs2071426

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.315
Position:
96828323
SE (Ratio):
0.024
Effect Allele:
C
Z-score (Ratio):
-13.188
Reference Allele:
T
-log10(P):
-89.768
MAF:
0.282
Beta (Num):
-0.115
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.200
SE (Den):
0.017
No CNV overlap
rQTL cluster:
71
Reaction Distance:
NA
Closest Genes:
CYP2C8 CYP2C9 C10orf129 PDLIM1 CYP2C19

LLM Analysis

Numerator Metabolite Explanation:

Steroidogenesis, Estrogen biosynthesis4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Furanoid fatty acid metabolism7[1], 8[2]

Ratio Explanation:

The ratio reflects differential metabolism by CYP2C enzymes; 16a-hydroxy DHEA 3-sulfate is a known steroid metabolite, while 3-CMPFP is a furan fatty acid metabolite.1[1], 7[2], 3[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in CYP2C8/CYP2C9 alter steroid metabolism.3[1], 9[2] Both CYP2C8 and CYP2C9 have been linked to glaucoma, potentially through altered metabolism of endogenous compounds that affect ocular health.10[3], 11[4], 12[5]

Phenotype Driver:

Gene-centric:CYP2C8/CYP2C9

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data