16a-hydroxy dhea 3-sulfate to androsterone glucuronide

Numerator Metabolite

Structure of 16a-hydroxy dhea 3-sulfate
Metabolite Accession: GCST90199863
Name: 16a-hydroxy dhea 3-sulfate
Hmdb Id: HMDB0062544
Super Pathway: NA
Sub Pathway: NA
Inchikey: ALBNSVAJDFJRKQ

Denominator Metabolite

Structure of androsterone glucuronide
Metabolite Accession: GCST90200688
Name: androsterone glucuronide
Hmdb Id: HMDB0002829
Super Pathway: NA
Sub Pathway: NA
Inchikey: VFUIRAVTUVCQTF

Associated Genomic Regions

Region: rs148982377

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
7
Beta (Ratio):
1.235
Position:
99075038
SE (Ratio):
0.044
Effect Allele:
C
Z-score (Ratio):
27.775
Reference Allele:
T
-log10(P):
-389.268
MAF:
0.034
Beta (Num):
1.044
Novel Locus:
No
SE (Num):
0.039
Beta (Den):
-0.191
SE (Den):
0.037
No CNV overlap
rQTL cluster:
90
Reaction Distance:
NA
Closest Genes:
ZNF789 ZNF394 ATP5J2 ATP5J2-PTCD1 PTCD1

LLM Analysis

Numerator Metabolite Explanation:

Steroid biosynthesis and metabolism.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Steroid biosynthesis and metabolism.10[1], 11[2], 12[3]

Ratio Explanation:

The ratio reflects competing steroid hormone conjugation pathways, sulfation (numerator) versus glucuronidation (denominator), with genetic variation in SULT2A1 influencing the balance.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in SULT2A1 are associated with cholelithiasis risk.4[1], 5[2], 6[3] Altered SULT2A1 activity likely modifies steroid and bile acid metabolism, which is a key factor in gallstone formation, connecting the gene, the steroid ratio, and the phenotype.13[4], 14[5], 15[6]

Phenotype Driver:

Gene-centric:SULT2A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data