gamma-cehc to glycine conjugate of c10h14o2 (1)*

Numerator Metabolite

Structure of gamma-cehc
Metabolite Accession: GCST90199864
Name: gamma-cehc
Hmdb Id: HMDB0001931
Super Pathway: NA
Sub Pathway: NA
Inchikey: VMJQLPNCUPGMNQ

Denominator Metabolite

Metabolite Accession: GCST90200175
Name: glycine conjugate of c10h14o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs9461218

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.168
Position:
25818755
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
-7.692
Reference Allele:
G
-log10(P):
-31.866
MAF:
0.236
Beta (Num):
-0.088
Novel Locus:
Yes ✔️
SE (Num):
0.018
Beta (Den):
0.081
SE (Den):
0.018
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Vitamin E metabolism.9[1], 10[2], 11[3], 12[4], 13[5]

Denominator Metabolite Explanation:

Xenobiotic metabolism, Glycine conjugation.

Ratio Explanation:

The ratio likely reflects the relative renal clearance of gamma-CEHC versus the glycine conjugate, potentially mediated by SLC17A family organic anion transporters.1[1], 2[2], 8[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in SLC17A1/A3 alters renal transport, impacting both the metabolite ratio and, more critically, serum uric acid levels.1[1], 2[2], 4[3] Elevated uric acid is associated with increased pulse pressure and can affect hematocrit and hemoglobin, linking the gene to the observed phenotypes.14[4]

Phenotype Driver:

Gene-centric:SLC17A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data