gamma-cehc to glycine conjugate of c10h12o2*

Numerator Metabolite

Structure of gamma-cehc
Metabolite Accession: GCST90199864
Name: gamma-cehc
Hmdb Id: HMDB0001931
Super Pathway: NA
Sub Pathway: NA
Inchikey: VMJQLPNCUPGMNQ

Denominator Metabolite

Metabolite Accession: GCST90200182
Name: glycine conjugate of c10h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs9461218

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.207
Position:
25818755
SE (Ratio):
0.024
Effect Allele:
A
Z-score (Ratio):
-8.554
Reference Allele:
G
-log10(P):
-38.969
MAF:
0.236
Beta (Num):
-0.088
Novel Locus:
Yes ✔️
SE (Num):
0.018
Beta (Den):
0.119
SE (Den):
0.021
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Vitamin E metabolism3[1]

Denominator Metabolite Explanation:

Xenobiotic metabolism4[1]

Ratio Explanation:

The ratio likely reflects the balance between vitamin E degradation and xenobiotic detoxification, potentially influenced by shared renal clearance pathways mediated by SLC17A3.1[1], 3[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

SLC17A3 variants may alter the excretion of both gamma-CEHC and the glycine conjugate, and its primary role in urate transport explains the strong association with uric acid levels, which in turn are linked to red blood cell parameters.1[1], 2[2], 5[3]

Phenotype Driver:

Gene-centric:SLC17A3

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data