tridecenedioate (c13:1-dc)* to decadienedioic acid (c10:2-dc)**

Numerator Metabolite

Metabolite Accession: GCST90199867
Name: tridecenedioate (c13:1-dc)*
Hmdb Id: HMDB02327
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of decadienedioic acid (c10:2-dc)**
Metabolite Accession: GCST90200700
Name: decadienedioic acid (c10:2-dc)**
Hmdb Id: HMDB0242172
Super Pathway: NA
Sub Pathway: NA
Inchikey: FRWVXIATCBRYHA

Associated Genomic Regions

Region: rs1359232

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.217
Position:
25809716
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-12.615
Reference Allele:
C
-log10(P):
-82.336
MAF:
0.445
Beta (Num):
-0.053
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.163
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.4[1]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.5[1], 6[2]

Ratio Explanation:

The ratio of tridecenedioate to decadienedioic acid may reflect altered omega-oxidation of different chain-length fatty acids or differential transport by SLC17A4.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 gene's primary role as a urate transporter is strongly linked to the uric acid phenotype.2[1], 7[2], 8[3], 9[4], 10[5] Hematological traits (MCHC, MCH, Hb, Ht, MCV) might be influenced by its phosphate transport function or secondary to renal function changes.1[6], 11[7]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data