androstenediol (3beta,17beta) monosulfate (2) to xanthurenate

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of xanthurenate
Metabolite Accession: GCST90199626
Name: xanthurenate
Hmdb Id: HMDB0000881
Super Pathway: NA
Sub Pathway: NA
Inchikey: FBZONXHGGPHHIY

Associated Genomic Regions

Region: rs1165152

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.193
Position:
25818766
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
9.136
Reference Allele:
G
-log10(P):
-44.179
MAF:
0.446
Beta (Num):
0.086
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.108
SE (Den):
0.016
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Androgen and Steroid Metabolism

Denominator Metabolite Explanation:

Tryptophan Metabolism, Kynurenine Pathway5[1], 6[2]

Ratio Explanation:

The SLC17A4 transporter may influence the clearance of both androstenediol monosulfate (anionic steroid) and xanthurenate (anionic tryptophan metabolite), affecting their circulating ratio.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC17A4 function likely modifies urate transport, explaining associations with uric acid, MCHC, MCH, and other hematological and renal phenotypes.7[1], 1[2], 8[3], 9[4] The ratio reflects broad substrate transport by this gene.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data