androstenediol (3beta,17beta) monosulfate (2) to DHEAS

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of dehydroepiandrosterone sulfate (dhea-s)
Metabolite Accession: GCST90199673
Name: dehydroepiandrosterone sulfate (dhea-s)
Hmdb Id: HMDB0001032
Super Pathway: NA
Sub Pathway: NA
Inchikey: CZWCKYRVOZZJNM

Associated Genomic Regions

Region: rs2900478

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.175
Position:
21368797
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-10.758
Reference Allele:
T
-log10(P):
-60.472
MAF:
0.165
Beta (Num):
-0.113
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.062
SE (Den):
0.018
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism.7[1], 8[2]

Denominator Metabolite Explanation:

Steroidogenesis, Androgen and estrogen metabolism.9[1], 10[2], 11[3], 12[4]

Ratio Explanation:

Reduced SLCO1B1 function likely impairs hepatic uptake of both sulfated steroids, altering their circulating ratio and subsequent metabolism and clearance.13[1], 8[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1-mediated hepatic uptake of urate and bilirubin precursors likely contributes to hyperuricemia, gout, and elevated bilirubin.1[1], 14[2], 15[3], 16[4] Altered steroid transport may also play a role, but the link is less direct.13[5], 8[6]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data