androstenediol (3beta,17beta) monosulfate (2) to epiandrosterone sulfate

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of epiandrosterone sulfate
Metabolite Accession: GCST90199752
Name: epiandrosterone sulfate
Hmdb Id: HMDB0062657
Super Pathway: NA
Sub Pathway: NA
Inchikey: ZMITXKRGXGRMKS

Associated Genomic Regions

Region: rs73079476

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.164
Position:
21343833
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
-8.083
Reference Allele:
A
-log10(P):
-34.997
MAF:
0.155
Beta (Num):
-0.117
Novel Locus:
Yes ✔️
SE (Num):
0.021
Beta (Den):
0.047
SE (Den):
0.020
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen metabolism.7[1], 8[2], 9[3], 10[4]

Denominator Metabolite Explanation:

Androgen and estrogen metabolism.11[1], 12[2], 13[3]

Ratio Explanation:

The liver transporter SLCO1B1 may clear both sulfated steroids; impaired function could alter the ratio of androstenediol (3beta,17beta) monosulfate to epiandrosterone sulfate.14[1], 15[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function directly impacts bilirubin clearance, explaining the association with Total Bilirubin levels.16[1], 17[2] This genetic link to altered bilirubin metabolism and transport is also associated with coronary atherosclerosis risk.18[3], 19[4], 20[5], 21[6]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data