androstenediol (3beta,17beta) monosulfate (2) to 1-palmitoleoyl-gpc (16:1)*

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of 1-palmitoleoyl-gpc (16:1)*
Metabolite Accession: GCST90199777
Name: 1-palmitoleoyl-gpc (16:1)*
Hmdb Id: HMDB0010383
Super Pathway: NA
Sub Pathway: NA
Inchikey: LFUDDCMNKWEORN

Associated Genomic Regions

Region: rs2900478

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.230
Position:
21368797
SE (Ratio):
0.026
Effect Allele:
A
Z-score (Ratio):
-9.006
Reference Allele:
T
-log10(P):
-42.988
MAF:
0.165
Beta (Num):
-0.113
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.117
SE (Den):
0.020
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1A2 SLCO1B7 LST3

LLM Analysis

Numerator Metabolite Explanation:

Androgen and estrogen biosynthesis.6[1]

Denominator Metabolite Explanation:

Phospholipid and lysophospholipid metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

SLCO1B1 variants impact the transport of both steroid sulfates and lipids, altering the balance between androgen precursors and cell membrane components.10[1], 11[2], 12[3], 13[4], 14[5], 15[6], 16[7]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function alters the transport of its substrates, including androstenediol monosulfate, lipids, and urate.11[1], 17[2], 12[3], 13[4] This disruption contributes to hyperuricemia and gout.18[5], 19[6], 17[7], 20[8]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data