androstenediol (3beta,17beta) monosulfate (2) to 1-stearoyl-gpg (18:0)

Numerator Metabolite

Structure of androstenediol (3beta,17beta) monosulfate (2)
Metabolite Accession: GCST90199871
Name: androstenediol (3beta,17beta) monosulfate (2)
Hmdb Id: HMDB0240429,HMDB0186954
Super Pathway: NA
Sub Pathway: NA
Inchikey: KMTOEENORMWLCF

Denominator Metabolite

Structure of 1-stearoyl-gpg (18:0)
Metabolite Accession: GCST90199780
Name: 1-stearoyl-gpg (18:0)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: HFJVKBVEKQHVTO

Associated Genomic Regions

Region: rs4149056

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.343
Position:
21331549
SE (Ratio):
0.029
Effect Allele:
C
Z-score (Ratio):
-11.699
Reference Allele:
T
-log10(P):
-71.122
MAF:
0.155
Beta (Num):
-0.113
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.230
SE (Den):
0.023
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 SLCO1A2 LST3

LLM Analysis

Numerator Metabolite Explanation:

Steroid hormone biosynthesis.5[1], 6[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.7[1], 8[2]

Ratio Explanation:

Altered SLCO1B1 function likely affects the transport of both androstenediol monosulfate (a steroid hormone) and lysophosphatidylglycerols from the blood into the liver.9[1], 10[2], 11[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function can lead to increased circulating levels of its substrates, potentially contributing to hyperbilirubinemia, altered drug responses, and impacting phenotypes like gout and cardiovascular diseases.12[1], 13[2], 14[3], 15[4]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data